Nail fungal disease affecting efficacy of factor analysis

With the continuous development and application of antifungal agents,
the efficacy of treatment of nail fungal diseases has been significant
progress. However, the
Articles published during the show the efficacy of nail fungal
diseases in different patients, different drugs are very different
between the two groups. As a
993 ~ April 2002 in the core of the domestic three dermatology
journals published Itraconazole treatment of nail fungal diseases
80 articles, treatment, cure rate of 40% to 100%, nail fungus disease
overall cure rate is 91.33%, toenail fungus disease overall
Cure rate was 85.59%, the recurrence rate was 1.26% [1]. In other
countries, about 25% ~ 40% of the clinical patient belongs to
Treatment failure, including the original recurrence of infection or
new infections [2]. In China, a long-term follow-up study
Show that using the standard oral drug therapy in patients three years
after the recurrence rate was 22.2% [3].

A nail fungus disease susceptibility factors

Nail fungal disease widely prevalent in the world, according to RJHAY
reported incidence in Europe is generally 3% to 22
% [2]; according to a survey conducted in China in 2000, dermatology
outpatient clinic patients, 15.6% of patients with toe nail fungus
Infection [4]. In different populations, disease incidence difference
was significant. In people suffering from peripheral vascular disease
Groups in the incidence of this disease for more than 40%; in older
age groups in the incidence of this disease by nearly 50%; psoriasis,
diabetes mellitus
Also exposes patients susceptible to this disease [2]. The use of
corticosteroids, immunosuppressive agents in the crowd, patients also
stipulates that
Significantly increased.

Two factors that affect the efficacy of nail fungus

2.1 A severity of disease with nail fungus disease related to clinical
classification. 1972 Zaias will nail fungus disease
Is divided into three types: white superficial nail fungus disease
(SWO), proximal subungual type nail fungus disease (PSO), distal
subungual
Type nail fungus disease (DLSO). At present, will be divided into five
clinical types, in addition to the above-mentioned three types, there
are full-A nutritional
Liang-type nail onychomycosis (TDO), a nail fungus disease in type
(EO). For the PSO, TDO, because the root involvement in patients with
a
, A disease severity significantly compared with DLSO, SWO, EO else.

The growth rate of 2.2 deck deck growth rate and disease A patient's
age, location and closely related.
Index finger, middle finger, ring finger nail the fastest growth rate
is about 3 times the thumb nail; while the thumb nail with 2 ~ 4-toed
The growth rate similar to toenail, toe nail growth rate were 1.5
times [5]. In different age groups
In the growth rate is also a significant difference: in 25 years ago,
a growth rate of the fastest; 30 ~ 60 years old, Health
Rates of growth decreased by 20% to 30%; to 80 years old, a growth
rate can be reduced by 50% [5].